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Vampire Rule N°25: A dead body is immune to poison.
A vampire would also be immune to most toxins, sleeping agents, paralytics, etc. Even if you could find something strong enough to affect a vampire anything short of directly injecting the stuff into the thing you want to affect (the brain, the spine, whatever the chemicals are meant to affect) likely isn't going to do much as the transfer method they all use, aka the blood, would be stagnant and not pumping if their heart isn't beating. This is for injections (the obvious), gases (they typically enter the blood stream from the lungs then to wherever they're supposed to go assuming he even decides to breathe for that to be an issue), putting it in food (again, bloodstream), etc.

All in all? There is a reason people don't typically go for trying to capture or subdue/knock out a vampire, it's practically impossible most of the time short of magic users or cutting open their skull for direct access to the brain, assuming that thing is even functioning properly and their thought process isn't just being handled by magic itself, and fighting one in close quarter to mid range even for someone like Batman would probably be near certain death if they aren't going for the kill.
 
A vampire would also be immune to most toxins, sleeping agents, paralytics, etc. Even if you could find something strong enough to affect a vampire anything short of directly injecting the stuff into the thing you want to affect (the brain, the spine, whatever the chemicals are meant to affect) likely isn't going to do much as the transfer method they all use, aka the blood, would be stagnant and not pumping if their heart isn't beating. This is for injections (the obvious), gases (they typically enter the blood stream from the lungs then to wherever they're supposed to go assuming he even decides to breathe for that to be an issue), putting it in food (again, bloodstream), etc.

All in all? There is a reason people don't typically go for trying to capture or subdue/knock out a vampire, it's practically impossible most of the time short of magic users or cutting open their skull for direct access to the brain, assuming that thing is even functioning properly and their thought process isn't just being handled by magic itself, and fighting one in close quarter to mid range even for someone like Batman would probably be near certain death if they aren't going for the kill.

Would something super corrosive work though? I wrote John as a blob of supernatural blood in human form, with most organs being there for no practical reason. Now that I think about it, do radiations affect a vampire?
 

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